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Stage 0: In this stage, the tumor affects only the top layer of cells and is often too small to be noticed

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In line with this model, CBD (0.11 M) reduces the efficacies and potencies of both 2-AG and THC by activating CB 1 R signaling in neurons in cell culture, and inhibits eCB-mediated synaptic plasticity without influencing excitatory transmission 234236