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Surveys of Americans in the 1940s found that about half of all adults said they smoked cigarettes

It is possible that the tar, nicotine, and carbon monoxide in cigarette smoke 40 activate ILC3s by binding to toll-like receptors and aryl hydrocarbon receptors 41

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For example, the FDA is proposing new regulations that would reduce the amount of nicotine in cigarettes to such a minuscule level that it can't be addictive

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