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Abbreviations BMI - body mass index COPD - chronic obstructive pulmonary disease CVD - cardiovascular disease DM - diabetes mellitus MI - myocardial infarction Footnotes Funding: This study was supported by a grant from the former Inspectorate for Health Protection and Veterinary Public Health, at present integrated in the Food and Consumer Product Safety Authority, The Netherlands

The most serious side effects include tendon rupture, permanent peripheral neuropathy, psychosis, aortic aneurysm, and severe allergic reactions (anaphylaxis)