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The interaction between the cigarette smoke and the epithelial lining fluid (ELF) enables further production of ROS in the airways, since both cigarette smoke and ELF contain metal ions, such as iron, which catalyze the production of free radicals [93]

[17] [18] In 1606, Philip III of Spain banned the cultivation of tobacco, though this ban was lifted in 1614

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In addition, the review found that the studies findings were mixed and the analyses were based on a small number of RCTs

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