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Abstract Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide

105 In its final report released in July 2011, TPSAC concluded that "removal of menthol cigarettes from the marketplace would benefit public health in the United States." 106 In July 2013, FDA released an advance notice of public rulemaking (ANPRM) on a tobacco product standard for menthol in cigarettes, seeking comments, data, research, and any other relevant information

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Clin Epigenetics (2016) 7:83.10.1186/s13148-016-0249-7 49 GaoXZhangYBreitlingLPBrennerH

1 2 3 4 5 6 Nikogosian, Haik (2010)