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Description
In 2016 the Royal College of Physicians concluded that "large-scale substitution of e-cigarettes, or other non-tobacco nicotine products, for tobacco smoking has the potential to prevent almost all the harm from smoking." Studies published in 2016 and 2017 showed that smokers who switch to e-cigarettes dramatically reduce their exposure to hazardous chemicals generated by tobacco combustionas dramatically as smokers who switch to nicotine replacement products such as gum or patches (a finding confirmed by a 2019 study of Juul e-cigarettes, the dominant brand in the United States)

As of October 8, 2019, the CDC is currently investigating around 1300 cases of EVALI and at least 26 vape-related deaths in 21 different states (3 occurred in California)
The impact of SHS exposure on health status and exacerbations among patients with COPD

Thirdhand smoke is the residue from secondhand smoke that settles on furniture, walls, carpeting, clothing, and other surfaces after someone has smoked in that area

62 Further research on the potential of heart and blood disease in e-cigarette users is still pending
In animal models, negative effects include blood-brain-barrier disruption, neuroinflammation and oxidative stress disbalance, altered epigenetic processes, and deregulated gene expression
