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In addition, the potential genetic changes in the nicotinic receptor expression with advancing age may also account for the moderate nicotine dependence found in heavy smokers

In 1950, four independent studies found that a high percentage of lung cancer patients were also heavy smokers

Toxicants present in CS and e-vapor increase secretion of ROS that can further induce cell stress responses, such as proinflammatory pathways, unfolded protein response pathways, and alterations in cell differentiation, including goblet cell hyperplasia [71]

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