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The 0.5 mg/mL inclusion is well below any clinical toxicity threshold and has no effect on tirzepatide's GIP or GLP-1 receptor binding

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A direct comparison in mice demonstrated that sequential prime-boost vaccination with their three constructs (6 vaccinations in total) induced a stronger antibody response than simultaneous vaccination (prime and then boost with a mixture of all three, 2 vaccinations in total) [149]

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