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Remarkably, altered intracellular calcium through TRPM8 has been previously shown to induce a neoplastic phenotype in LC [122]
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In addition, NSCLC is subdivided into three sub-types based mainly on the morphology of the transformed cells: adenocarcinoma (LUAD), squamous-cell carcinoma (LUSC), and large-cell carcinoma (LCC) [58]
