cigarette smoke induces cytoplasmic p53 accumulation Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers Phase Separation and Prion‐Like Aggregation
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[DOI] [PubMed] [Google Scholar] 90.Ala-aho R., Grnman R., Seth P., Khri V.-M

They were not common in the continental US until a new roll out made them available in October 2007

Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells

doi: 10.1182/blood.V99.9.3367

This is also why longer holders were for more formal occasions, which often had more elaborate dress codes

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