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DNA damage and autophagy

doi: 10.3389/fonc.2022.919118

Extracellular signal-regulated kinases and c-Jun N-terminal Kinase (JNK) promote the phosphorylation and activation of the activating protein-1 transcription factor (AP-1) components, which are primarily proteins from the Fos and Jun families

The authors showed that IKK triggered p53 phosphorylation and acetylation, upregulating the expression of its pro-apoptotic target genes [44]

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa

In the CSE+C646 group (final concentration of C646 was 12.5 M), we added 2 mL C646 solution to each well