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Herein, we review the emerging data regarding the aetiology and features of LCINS, particularly the genetic and environmental underpinnings of this disease as well as their implications for treatment

This idea implies a mediational relationship: Smoking is linked indirectly (mediation) to socioeconomic disadvantage through the experience of everyday stress, i.e., people would be assumed to smoke more as a response to experiencing higher levels of stress in their everyday lives through socioeconomic disadvantage

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Now, the tricky part is to roll the paper

This phenomenon, also called smoker's lips, is caused by the tobacco inside of cigarettes