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moderate certainty), but may result in little to no harm from other adverse events, such as hiccups, gastrointestinal disturbances, skin irritation from patches, throat irritation, or runny nose.43 Varenicline results in small harms from increases in nausea (32 RCTs, n = 14 963

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Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure: a randomized clinical trial

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