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Demand declined after the Surgeon Generals report in 1964 linked cigarettes to lung cancer, and continued to fall after the Master Settlement Agreement in 1998 restricted tobacco advertising and marketing

Physical Dependence: Nicotine addiction often involves strong physical dependence, with users experiencing intense cravings and withdrawal symptoms, whereas caffeine addiction tends to be more psychological, with fewer severe physical withdrawal symptoms

Some packaging does not mention tobacco as an ingredient, and some brands are pitched as candies - featuring packaging with children's faces and are brightly colored

Replacing the kit is easy, since the front panel snaps off

A sign of things to come is the sharp decline in all tobacco types after 2004, when the allotment and price support program was phased out

Figure 1.5 Neuron structure