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Abbreviations AGEs: Advanced glycation end products AMPK: AMP-activated protein kinase CAT: Catalase COX-2: Cyclooxygenase-2 GSH-Px: Glutathione peroxidase GSH-Re: Glutathione reductase IL: Interleukin IFN-: Interferon-gamma MDA: Malondialdehyde MMPs: Matrix metalloproteinases mtROS: Mitochondrial reactive oxygen species ROS: Reactive oxygen species SASP: Senescence-Associated Secretory Phenotype SOD: Superoxide Dismutase TNF-: Tumor necrosis Factor-alpha TGF-: Transforming growth factor-beta TEWL: Transepidermal water loss NMF: Natural moisturizing factors ITA: Typology angle GPx: Glutathione peroxidase PUFAs: Polyunsaturated fatty acids LA: Linoleic acid ALA: Alpha-linolenic acid EPA: Eicosapentaenoic acid DHA: Docosahexaenoic acid AA: Arachidonic acid References Girsang E, Lister INE, Ginting CN, et al

471 Furthermore, old mice showed muscular degeneration correlated with high serum phosphate concentration and increased levels of integrin-linked kinase and p53, indicative of a possible mechanism in developing sarcopenia