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This network determines whether different cells (airway/alveolar epithelium, alveolar macrophages, neutrophils, T cells, etc.) ultimately undergo apoptosis, ferroptosis, necroptotic apoptosis, or pyroptosis, and profoundly affects whether the immune microenvironment of COPD shifts toward inflammatory resolution or inflammatory amplification (101)

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However, the difference between the groups fell just short of statistical significance after controlling for key baseline variables