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[29] The exact prevalence of Ni-ACD in the general population in the US is largely unknown

10.1016/j.psychres.2011.05.037 26

34 Functional polymorphisms in the genes coding for these enzymes allow for the identification of fast metabolizers, who have more rapid nicotine clearance and show greater cigarette intake and more intensive smoking topography profiles relative to normal or slow metabolizers

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PLoS ONE 10 , e0116732 (2015)

Our results show that nearly all of this reduction was concentrated in people with little or no disadvantage, despite recent tax hikes on smoking, stricter cigarette regulation, and available quit aids. Cigarette smoking is responsible for 480,000 deaths per year in the United States, according to the Centers for Disease Control and Prevention