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Azjifurther demonstrated the importance of TLR-4 in the pathogenesis of NEC, showing that a specific deletion in the TLR4 locus in endothelial cells in a mouse model of NEC was associated with a significant reduction in NEC severity when compared to endothelial TLR-4 sufficient animals 21

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10.1038/nm.3162 17 ChenJ.JiangX.GaoX.WuW.GuZ.YinG.et al (2023)