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Data availability The datasets generated during and/or analyzed during the current study are not publicly available as participants were informed that no-one outside of the research team would have access to the research data when they signed their consent forms

However, an important phenomenon implicated seems to be the inhibition and/or induction of isozymes of the cytochrome P450 (CYP) family among smokers [15]

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Nevertheless, MVP was utmost without or of little clinical consequence, valvular regurgitation with mild hemodynamic involvement was rare (~ 35%), and none of our patients required surgical intervention, in line with earlier reports [16, 20]

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