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Tobacco use also suppresses the expression of angiogenic markers such as vascular endothelial growth factor (VEGF), leading to decreased blood supply and impaired vascularization, which are crucial for bone healing

Some key biological causes include: Neurochemical Changes: Nicotine, the primary psychoactive component of tobacco, interacts with nicotinic acetylcholine receptors in the brain, leading to the release of neurotransmitters such as dopamine, as discussed by Berrendero, F

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