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73159 International Agency for Research on Cancer

p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3

Hepatitis C virus core protein overcomes H2O2-induced apoptosis by downregulating p14 expression via DNA methylation

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

In diffuse intrinsic pontine gliomas, mutations in p53 are a major driver of increased radiation resistance, with mutp53 carrying patients less responsive to irradiation and relapsing earlier after radiotherapy with a worse prognosis [114]

In the cytoplasm of infected hepatocytes, HBeAg can promote MDM2-mediated p53 ubiquitination and degradation, and impair the transcriptional activity of p53 by interacting with NUMB (a positive regulator of p53) 75
