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Before West Virginia is admitted to the Union as a distinct state (in 1863) there were actually three separate governments operating within the confines of the state of Virginia: one part of the confederacy, one part of the Union and one hopeful of becoming a separate state

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Alleles S and Z encode abnormal proteins that polymerize in the liver, and therefore, 80-90% of PiZ and 40-50% of PiS molecules are retained inside the hepatocyte-forming polymers, usually degraded by the proteasome

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