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For example, Type 2 diabetes mellitus without complications - E11.9 Family history of malignant neoplasm of breast - Z80.3 Tobacco use - Z72.0 Many countries use their own national variation of ICD-10 with key modifiers to align with their unique healthcare infrastructure

These genetic differences explain why only 10-20% of smokers never become addicted despite nicotine exposure, highlighting the biological basis of addiction vulnerability

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