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Nicotine is metabolized in the liver, primarily through enzymes that can be affected by other drugs

Melanin is the natural pigment responsible for lip and skin colour

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All species of Nicotiana contain the addictive drug nicotinea psychostimulant alkaloid found in all parts of the plants except the seeds, and most heavily concentrated in the leaveswhich occurs in varying amounts depending on the species of Nicotiana grown

What was once a landscape of swamps and tributaries has hardened into cracked earth, its surface fractured by drought