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It appeared in 1988

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Further research needs to be conducted using human subjects to replicate the findings "before the implications are fully understood," she added.

The reward pathway begins in the midbrain where cell bodies of neurons send long fibers to the prefrontal cortex

Ann Nutr Metab 2006, 50: 85-94.

But, epidemiological models may not fully account for the fact that people who are ill (or, especially people who are more likely to become ill) are more inclined to begin smoking, and more disinclined to discontinue smoking