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doi: 10.1056/NEJMoa1916433 [DOI] [PMC free article] [PubMed] [Google Scholar] 12.Glasser AM, Collins L, Pearson JL, Abudayyeh H, Niaura RS, Abrams DB, et al

the BPRF is a conservative risk function defined as the 5th quantile curve (for harmful risks) that reflects the smallest harmful effect at each level of exposure consistent with the available evidence

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The wide variety of dose ranges used leads to the question of the most relevant doses to use when assessing the toxicity of e-cigarettes

[67] Among experienced users there is a wide range in puffing time