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One of the earliest uses in English is in Rycharde Edens (Richard) translation of The decades of the newe worlde or west India , a text by Pietro Martire d Anghiera that was translated by Eden from Latin in 1555

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Within 7 seconds of inhaling tobacco smoke nicotine begins to bind to receptors within the central nervous system known as nicotinic acetylcholine receptors, or NCR's

In a final iteration, we tracked the references of and citations to relevant papers, thereby compiling additional studies

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