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Food and Drug Administration (FDA) Commissioner and the Center for Tobacco Products (CTP) Director stated in 2017, Nicotine, though not benign, is not directly responsible for the tobacco-caused cancer, lung disease, and heart disease that kill hundreds of thousands of Americans each year

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Although the smoking rate has decreased (from 41.2% in 1980 to 31.1% in 2012), owing to population growth, there has been an increase in the number of current cigarette smokers in the world (from 721 million in 1980 to 967 million in 2012) [30]