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In contrast to our tobacco smoking findings, we failed to find genetic evidence of respiratory implications due to alcohol consumption not meeting the threshold of AUD, or binge drinking, suggesting that previous observational literature may be due to confounding from other comorbid behaviorssuch as smokingthat may be the true causal risk factors for respiratory infections

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In aggregate, despite convincing evidence indicating that CSE enhances Th1 immune responses, which are of great importance in COPD pathogenesis and progression, data exist on CSE contribution to Th2 bias of lung immunity crucial for allergic sensitization and asthma