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It is important to note, though, that most of the health risks linked to smoking cigarettes come from chemicals other than nicotine

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[88] Youth who believe they are vaping without nicotine could still be inhaling nicotine because there are significant differences between declared and true nicotine content

In long-term or heavy use, reported issues include addiction (risk is 9% overall, but 17% for those who start use in adolescence, and up to 50% in those who are daily users), altered brain development, poor educational completion/outcomes, cognitive impairment (IQ levels impaired with frequent use during adolescence), diminished long-term life satisfaction, increased risk of psychotic disorders such as schizophrenia

Meyerhoff, D.J

Many experience a temporary increase in heart rate as their body recalibrates