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McDonough, A

Their effects on the individual components of MACE, myocardial infarction (reduced in LEADER and Harmony Outcomes), and stroke (reduced in SUSTAIN-6 and REWIND), varied in each trial (Table 1)

Lancet 376 (9739), 431439 (2010)

The dual receptor agonism could, therefore, counteract the two pathogenetic mechanisms of T2DM (adiposity-induced insulin resistance and pancreatic insulin deficiency) more effectively than selective mono-agonists [163]

doi:10.1038/s41598-018-37215-0 92
