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Description
55 Variants associated with nicotine dependence in the 5 / 3 / 4 gene region (chromosome 15, 15q25) also have a significant association with the number of cigarettes smoked per day, plasma levels of cotinine (a biomarker of nicotine intake), urine levels of tobacco-smoke carcinogens, and the risks of smoking-related diseases

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The horrid massacres by the Indians threatened the extermination of the colony, and for a time the plantations were neglected and even tobacco became more of an article of import than of export, which is substantiated by an early writer of the colony who says:"A vast quantity of tobacco is consumed in the country in smoking, chewing, and snuff." Frequent complaints were made by the colony of want of strength and danger of imminent famine, owing in (p
