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The ability of tirzepatide to maintain or add to WL achieved after an intensive lifestyle modification program will be investigated in SURMOUNT-3 when the SURMOUNT-4 will assess the effect of continuing tirzepatide vs switching to placebo on WL maintenance in adults with overweight or obesity

These include T cell activation and proliferation, B cell differentiation and chemotaxis of neutrophils and monocytes [38]

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Together, these results show that by competing with endogenous FOXO4 for p53 binding, FOXO4-DRI disrupts senescence-associated FOXO4/PML/DNA-SCARS and causes nuclear exclusion of active p53