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The lung undergoes a vast number of changes in response to e-cigarette use, and the development of lung disease will depend on how those changes interact with both environmental and genetic factors

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Methods: We commissioned systematic reviews on evidence of benefits and harms of smoking cessation interventions in adults, comprising an overview of Cochrane reviews on behavioural interventions, pharmacotherapy, and other interventions, and a systematic review on electronic cigarettes (e-cigarettes)

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