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Single-cell RNA sequencing studies in murine smoke models have identified an excessive influx of monocyte-derived macrophage subset population responsible for heightened inflammation and ECM remodeling, a finding that has also been validated in emphysematous COPD patients 59

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The researchers found that nearly a third (30%) of people in this group started smoking within five minutes of waking, compared to 13% of smokers who drank alcohol but were not at risk of dependence, and 17% of non-drinkers

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