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Similarly, short follow-ups (i.e., 36 months) may not be sufficient to observe potential meaningful improvements or further assess harm attributable to only e-cigarette use

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It is worth considering that, although the present work focused on a subset of CpN sites within the mtDNA regions of mitochondrial promotor region (D-loop) and two mitochondrial protein coding genes ( MT-CYB and MT-CO2 ), LC-MS/MS analyses also showed no differential methylation induced by long-term CSE exposure

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