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Total nicotine (mg) = E-liquid volume (mL) Nicotine strength (mg/mL) Cigarette equivalent = Total nicotine 12 mg per cigarette Pack equivalent = Cigarette equivalent 20 Example: A 50,000-puff disposable with 22 mL of 50 mg/mL (5%) e-liquid contains 22 50 = 1,100 mg total nicotine about 92 cigarettes (1,100 12) or 4.6 packs