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Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease

The PATH Study design employed a stratified address-based, area probability sampling design at Wave 1 that oversampled adult tobacco users, young adults (aged 1824), and African American adults (i.e., this comprises the Wave 1 cohort)

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Each person may experience different symptoms

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AMBER The aroma is quite intense, but not sharp and not chemical