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Bonferroni multiple comparisons confirmed that there was a significant decrease in the latency to enter dark chamber in NIC and NIC/ASA15 compared to Control and ASA 30 mg/kg groups after 11 days of ASA 30 mg/kg treatment (Figure 3B)

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Particular care is needed for drugs with a narrow therapeutic index, such as clozapine, olanzapine and warfarin