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Nationally, the rate was 6.0%.2 Other tobacco product use: North Carolina Vaping rates in North Carolina In 2018, 5.1% of adults in North Carolina used e-cigarettes.3 In 2020, 3.9% of adults in North Carolina used smokeless tobacco.3 In 2019, 35.5% of high school students in North Carolina used electronic vapor products on at least one day in the past 30 days

In particular, according to DDIC and MedScape.com, RIF will decrease the level or effect of bupropion by inducing CYP2B6 activity

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We have added to the text of the Stage 5 section "Our manuscript will include a discussion section that will highlight important and or surprising results from this review, discuss additional research questions identified, discuss the limitations of this review, and comment on the quality of the evidence identified." We have also added "and discussion" to the first sentence of the Stage 5 section of our manuscript to clarify that the PRISMA- ScR checklist will be used to inform the writing of our discussion section in addition to our results section

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Per Wikipedias reference on tobacco types, a typical American cigarette is a blend of bright Virginia, burley, and Oriental, and Camel is the classic textbook example of the Oriental contribution