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Other symptoms include muscle pain in the lower back, buttocks, thighs, or knees, swollen and sometimes tender lymph nodes in the groin, with loss of appetite and fever

The extension study enrolled 4590 (57.2%) of the 8027 subjects who were randomized and treated in the parent study and followed them for additional 28 weeks

Lung function can improve gradually after quitting smoking

Researchers found that participants who were assigned to the gradual-quit group eventually lost motivation to quit as they relied on less harmful nicotine products, such as nicotine lozenges or nasal sprays, to assist them in their gradual cessation of smoking
