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In over 150 adolescents followed from 6 months to 5 years, higher basal cortisol levels (measured using nocturnal free urinary cortisol and salivary cortisol levels) correlated with an increased risk of smoking initiation and smoking persistence [109]

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Is arbitrary and capricious because it provides no meaningful justification for creating an enforcement safe harbor or changing the agencys longstanding approach to flavored products, which the FDA has consistently identified as a major driver of youth use