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E-cigarettes are considered tobacco products because most of them contain nicotine, which comes from tobacco

Cotinine, the main metabolite of nicotine, has often been used as a measure of smoking exposure

[DOI] [PubMed] [Google Scholar] [69].Ray Chaudhuri A, Nussenzweig A, The multifaceted roles of PARP1 in DNA repair and chromatin remodelling, Nature reviews

They are in the same group of people who have a tendency to start smoking cannabis as teenagers. In other words, socioeconomic factors are entering the equasion

While herbal cigarettes eliminate nicotine (the addictive substance in tobacco), they still involve burning plant materials and inhaling smoke, which can produce harmful substances

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