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Despite these strengths, several limitations should be noted

For Heavy Users: Nicotine Replacement Therapy If you use 10+ high-strength pouches daily, consider nicotine gum for the first 4-6 weeks

Its anti-androgenic effects reduce the impact of male hormones that contribute to these conditions

Over time, smokers develop a dependence on nicotine, making it challenging to quit smoking

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Increased clearance of the benzodiazepines alprazolam, lorazepam, oxazepam, diazepam and demethyl-diazepam is found in cigarette smokers, whereas chlordiazepoxide does not appear to be affected by smoking