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Identifying and functionally characterizing these microbial metabolites may lead to novel therapeutic strategies aimed at modulating the microbiome to mitigate disease risks and improve smoking cessation outcomes [144, 145]

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Alternatively, the high nicotine concentration in pouches makes it much more addictive and problematic

In 2019, this pattern was observed among those aged 15 years and over for all of the EU Member States, as well as all of the non-member countries shown in Figure 9