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4042 Clinical trial data clearly show that the metabolite ratio can be used to predict success in quitting, and that the likelihood of quitting decreases as the ratio increases, such that slower metabolizers are more successful at achieving abstinence

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It is also found that newborns exposed to tobacco smoke prenatally are associated with hypoactivity in inhibitory regions of the brain and decreased brain volume in cortical, white matter, or subcortical sections of the brain