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A post-hoc analysis suggests a higher abstinence rate with varenicline compared to bupropion or NRT (79), but with all three pharmacological interventions (bupropion, varenicline, NRT) being, by large, equally effective for TUD or ND (80), safety comes to the fore

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This is because most people are already aware of just how bad smoking is

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[31] Tobacco smoke contains 100 known carcinogens and 900 potentially cancer-causing chemicals, but e-cigarette vapor contains fewer potential carcinogens than tobacco smoke