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In addition, within the adolescent M1, maladaptive changes in 5-HT signaling and 5-HT 1A activity after nicotine or fluoxetine exposure may potentiate hyper-responsiveness to dopaminergic drugs and prime adolescent vulnerability for future substance abuse

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Drug Abuse and AddictionDrug abuse and addiction is a chronic disease that causes drug-seeking behavior and drug use despite negative consequences to the user and those around him

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Nicotine can cause health problems, such as irregular heart rhythm and heart rate changes