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Sharpe, Nobel Prize in Economics Below is a comparison of annualized returns, net of fees (TER), using the US dollar versions of the MSCI World and S&P 500 as of December 31, 2024: Analysis: The S&P 500 has historically outperformed the MSCI World, largely due to the strength of US tech giants like Apple, Microsoft and NVIDIA in recent years

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Of note, public health initiatives often incorporate cost-effectiveness analyses to evaluate the impact of interventions and allocate resources efficiently