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This Burley leaf is grown in the USA, and for those that are familiar with our conventionally grown Burley and our " Organic American Virginia Flue Cured Tobacco Leaf", this leaf is a middle ground between the two, except Organic

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In addition, tolerance usually occurs, since each time a higher dose is required to achieve the desired effect or to maintain the normal state of the organism (5)

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Supplementary Materials Data Availability Statement The data underlying this article will be shared on reasonable request to the corresponding author upon the publication of all planned research from the project.